Molecular investigation of the MAPKAPK2 signaling pathway

Master’s Thesis in Translational DNA Damage Biology

10.08.2026, Diplomarbeiten, Bachelor- und Masterarbeiten

Why do some cancer cells survive treatment with nucleoside analogues? This experimental Master’s thesis investigates how MAPKAPK2 (MK2) signalling and cell-cycle regulation contribute to drug resistance.

Nucleoside analogues are important anticancer drugs, yet some cancer cells survive treatment. In this experimental Master’s thesis, you will investigate the molecular mechanisms behind this escape.

You will validate promising screening hits using Celigo-based assays and Western blotting, examine their effects on the cell cycle, and determine whether they reverse a shared MK2-dependent resistance mechanism.

The project offers:

- A focused research question with translational relevance

- Ownership of an experimental project from validation to mechanistic insight

- Training in mammalian cell culture, Celigo imaging, Western blotting, cell-cycle analysis, and quantitative data analysis

- Close scientific supervision

You will join a young and collaborative research group at the Department of Medicine II, TUM Klinikum Rechts der Isar. Located in central Munich near Max-Weber-Platz, our group combines molecular cancer biology with clinically relevant questions in a supportive and hands-on research environment.

We are looking for a curious and motivated Master’s student in biology, biochemistry, biomedical sciences, medicine, or a related field. Previous laboratory experience is helpful, but enthusiasm for experimental cancer research, reliability, and willingness to learn are most important.


Department of Medicine IITUM Klinikum Rechts der IsarIsmaninger Straße 2281675 Munich

Projected starting date: 15 October 2026

Kontakt: yizhu.li@tum.de

More Information

https://med2.mri.tum.de/de/Forschung%20%26%20Lehre/grundlagenforschung-und-translationale-forschung/ag-li