Master’s Thesis: Simulation of Fiber-Optic Ultrasound Detection for Non-Invasive Glucose Monitoring

27.11.2025, Diplomarbeiten, Bachelor- und Masterarbeiten

This thesis is about the development and enhancement of existing simulations for fiber-optic ultrasound detection in combination with mid-IR optoacoustics. The outcome of this work will be directly applied in our experimental setup with the option for you to conduct these experiments on your own.

Master’s Thesis: Simulation of Fiber-Optic Ultrasound Detection for Non-Invasive Glucose Monitoring

As part of the EU-funded GLUMON project, we are developing a novel approach for non-invasive glucose monitoring based on mid-infrared optoacoustic spectroscopy. This technology aims to enable continuous and pain-free blood glucose measurement and represents a meaningful step forward in diabetes care.

In this thesis, you will investigate the combination of mid-infrared spectroscopy and fiber-optic ultrasound detection using COMSOL Multiphysics. Your work will contribute to an in-silico study of a miniaturized non-invasive glucose probe.

Thesis Objectives

Development and refinement of simulation models for mid-IR optoacoustic excitation combined with fiber-optic ultrasound detection. The results of your simulation will be compared to available experimental data. Experimental validation can optionally be carried out by you if you are interested in a combined simulation and lab-based thesis.

Tasks

• Conduct a literature review on optoacoustic signal generation and ultrasound propagation in different media
• Develop and refine a coupled simulation in COMSOL Multiphysics
• Validate your results against existing experimental data
• Optional: acquire and characterize additional experimental data in our laboratory if this aligns with your interests

Requirements

• Master’s student (m/f/d) in Physics, Computer Science, Electrical Engineering, Mechanical Engineering or a related field
• Solid programming skills in Python or MATLAB
• Good understanding of optical and acoustic (ultrasound) principles
• Experience with COMSOL is a big plus

What We Offer

• The opportunity to contribute to a cutting-edge, interdisciplinary research topic with real-world impact
• The freedom to shape the focus of the thesis according to your strengths and interests while receiving structured guidance and support
• Access to a state-of-the-art technology laboratory for simulation and experimental work
• Collaboration with a MedTech startup
• Flexible working conditions including a mix of on-site and remote work

Interested?

Send an E-Mail including a Letter of Motivation and your latest Transcript of Records to: maximilian.gotsch@tum.de

Kontakt: maximilian.gotsch@tum.de

More Information

https://www.helmholtz-munich.de/ibmi/ibmi-biochemical-and-environmental-sensors