MK2 kinase inhibitor drug synergy screen

Master thesis in Molecular Oncology from May 2025

14.01.2025, Abschlussarbeiten, Bachelor- und Masterarbeiten

The research group of „Translational DNA damage modification” is actively looking for a Master student with a life science background to conduct thesis work on the topic of molecular oncology, translational chemotherapy and DNA damage modification starting in May 2025.

We are a young research group located at the 2nd Medical Clinic at the TUM Klinikum rechts der Isar, focusing on solid tumor malignancies of the gastrointestinal tract. In our lab we apply a wide range of different techniques from cellular biology to in vivo mouse cancer models, innovative novel chemotherapies and targeted cancer selectivity.

We are offering a Master’s thesis project focused on the role of MK2 kinase in the DNA damage response and its potential as a therapeutic target in pancreatic cancer. The project involves cutting-edge phosphoproteomic techniques to identify novel downstream targets of MK2 in pancreatic cancer cells and organoids, using the MK2 inhibitor ATI-450 in combination with chemotherapeutic agents. This research provides an exciting opportunity to contribute to the understanding of DNA damage regulation and explore innovative strategies for improving cancer treatment.

The candidate is ideally highly motivated to participate in every day lab work and life, has a strong sense of responsibility for the thesis work and strong ambitions to contribute actively in the data generating and publishing processes for scientific manuscripts. Furthermore the candidate exhibits a strong interest in the molecular mechanisms of cancer physiology and clinical oncology.

Extensive wet lab experience is of advantage. If available, positive references are ideally mentioned. Please include a letter of motivation, a CV, previous graduation certificates, current transcripts, and address your application to: yizhu.li@tum.de

Kontakt: yizhu.li@tum.de

Mehr Information

https://www.med2.mri.tum.de/en/research/ag-li.php