Proteomics and Glycomics Analysis Using Mass Spectrometry Imaging

Master Thesis: Tissue Typing of Prostate Cancer

04.09.2025, Diplomarbeiten, Bachelor- und Masterarbeiten

This thesis project explores the molecular landscape of prostate cancer by combining proteomics and glycomics through mass spectrometry imaging (MSI). By profiling both proteins and glycans directly in tissue, you will help uncover new biomarkers and gain deeper insights into tumor biology and disease heterogeneity.

Prostate cancer development is accompanied by profound molecular changes in both protein expression and glycosylation patterns. These molecular alterations are promising candidates for improved diagnosis, prognosis, and therapeutic strategies.

In this project, you will apply MSI to map proteins and glycans within prostate tissues, enabling spatially resolved molecular profiling that links biochemistry with histopathology. This integrative approach opens the door to a more precise understanding of prostate cancer biology.

What you will gain 🚀

• Hands-on experience in mass spectrometry imaging
• Solid knowledge of proteomics and glycomics
• Insights into tumor pathology

Requirements 📌

Availability for laboratory work 2–3 days per week on-site at the Institute of Pathology, Technical University of Munich (TUM).

How to apply 💡

If you are interested, please send us an email introducing yourself and explaining why you would like to join this project. For questions or further information, feel free to get in touch:

📧 Dr. Juliana Gonçalves
juliana.goncalves@tum.de

Don’t miss this chance to take part in cutting-edge research and contribute to advancing personalized medicine in prostate cancer!

Kontakt: juliana.goncalves@tum.de

More Information

https://www.pm.mh.tum.de/en/path/research/schwamborn-lab-mass-spec-imaging/