Thesis/Internship: Construction of an EBC inlet

24.07.2025, Abschlussarbeiten, Bachelor- und Masterarbeiten

Construction of a new inlet design for Expanded Bed Chromatography.

Project:
Expanded Bed Chromatography (EBC) is a technique used for purifying substances such as proteins from a crude feedstock. The separation matrix consists of particles of various sizes within a vertically arranged column. For the purification, the particles are fluidized from below with a liquid. Based on their size, density, and the flow rate, the particles ascend to specific levels, forming a stratified expanded bed.
For stable bed expansion, a uniform fluid distribution across the inlet's column diameter is essential. Currently, a porous plate is used, which shows nonuniform fluid distribution. Therefore, a new inlet design is sought that is compatible with commercial column systems and doesn’t show dead zones.

Tasks:
- Designing 3D models of different inlet designs through CAD software
- Simulation of the flow distribution through the inlets into the column
- Building the inlets, e.g., through 3D printing
- Experimental validation of the simulations

If interested, please send:
- CV
- Transcript of records

Kontakt: n.kohn@tum.de

Mehr Information

https://www.epe.ed.tum.de/fileadmin/w00bzo/biose/20250724_NK_Construction_EBC_inlet.pdf