Modeling and simulation of Expanded Bed Chromatography

24.07.2025, Abschlussarbeiten, Bachelor- und Masterarbeiten

Internship: Modeling and simulation of Expanded Bed Chromatography

Project:
Expanded Bed Chromatography (EBC) is a technique used for purifying substances such as proteins. The separation matrix consists of particles of various sizes arranged within a column and fluidized from below. Based on their size, density, and the flow rate, the particles ascend to specific levels, forming a stratified expanded bed. Typically, numerous experiments are needed to optimize process parameters. However, by implementing an appropriate model, the number of required experiments can be minimized through simulation. Additionally, the model can offer deeper insights into the physical dynamics of bed expansion.

Tasks:
- Explanation of the physical processes during bed expansion
- Implementation of a suitable model for simulation
- Simulation of a bed expansion depending on column and particle properties and flow rate
- Optional: Simulation of the flow of molecules through an expanded bed
- Validation of simulation results with experimental data

If you're interested, please send
- CV
- Transcript of records
to n.kohn@tum.de

Kontakt: n.kohn@tum.de

Mehr Information

https://www.epe.ed.tum.de/fileadmin/w00bzo/biose/20241113_NK_simulation_EBC.pdf