Purification of Antibodies using Magnetic Nanoparticles - Master thesis

02.06.2025, Abschlussarbeiten, Bachelor- und Masterarbeiten

Master thesis - Start ASAP

In this research project, antibodies should be purified from a highly complex matrix for later application in the food and cosmetic industry.

The focus of this work will be the process optimization for the purification of using magnetic nanoparticles. Therefore, different parameters need to be investigated like:

Establishing a HPLC method for antibody quantification
Analysis of samples by mass spectrometry
Synthesis of magnetic nanoparticles
Particle to protein ratio, pH value
Reusability
Scale-up to pilot scale using high gradient magnetic separation
Process optimization


Your Tasks
Synthesis of particles
Analytics
SDS Page
HPLC
Plate assays
Large scale purification
Filtration

Your Profile
Independent and structured way of working
Experience with laboratory work
Student in the field of biotechnology, biochemical engineering chemistry or similiar


Please send your CV and transcript of records
Only for students of the TUM

Kontakt: j.galbusera@tum.de