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Sitemap Bulletin Board Diplomarbeiten, Bachelor- und Masterarbeiten

Diplomarbeiten, Bachelor- und Masterarbeiten

Sie suchen gerade eine Diplomarbeit, ein Thema für eine Bachelor oder Master Thesis? Dann sind Sie hier richtig. In diesem Bereich sind Abschlussarbeiten aus allen Fakultäten zu finden.
Beachten Sie auch den entsprechenden Stichwortindex.

Wenn Sie selbst eine Diplomarbeit ausschreiben wollen, lesen Sie bitte vorher unbedingt das 'Best Practice Manual Stellenanzeigen'.

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28.01.2016
Internship/Master's thesis

Master’s thesis project available Stability of regulatory T cells in Type 1 Diabetes – role of epigenetic modifica-tions and microRNAs Type 1 Diabetes (T1D) is characterized by a breakdown of immunological self-tolerance to insulin producing islet beta cells and consequently their destruction by autoreactive T cells. The onset of islet autoimmunity (pre-T1D) is indicated by the appearance of islet autoantibodies which marks a point of limited return in the pathogenesis of T1D in children. However, the time span of the progression to clinical T1D is highly variable, indicating that various mechanisms of immune acti-vation and tolerance are involved. In healthiness peripheral self-tolerance is maintained by a specific lineage of T cells that actively suppresses autoreactive T cells. These regulatory T cells (Tregs) are characterized by the expression of the transcription factor Foxp3 which func-tions as a master regulator for Treg function and development. In addition to their regulatory function Tregs can be transferred, are stable and keep up their function for a long time which makes them a promising research field, aiming at the clinical application in autoimmune disease prevention and therapy. Epigenetic modifica-tions like DNA methylation affect gene transcription by altering the accessibility of distinct DNA regions to transcription factors. There are Treg specific hypomethyl-ated regions in the Foxp3 gene which are highly stable in Tregs occurring in vivo. Interspecies conservation plots highlighted four conserved non-coding sequences (CNS) within the Foxp3 locus that control transcription via epigenetic regulation: the Foxp3 promoter, the TGFβ sensor (CNS1), the TSDR (CNS2) and CNS3. We em-ploy in vitro Treg induction systems to study mechanisms of Treg induction and stability. The dissection of underlying epigenetic mechanisms of Treg induction and the targeted manipulation of methylation events will be critical to obtain fur-ther insights into the biology of Tregs. These advances will contribute to improve their stable induction, aiming at prevention and therapy of unwanted immunity. The current project is offered to characterize the methylation status of different T cell subsets and especially the methylation dynamics during Treg induction as well as the targeted manipulation of methylation. Methods to be employed include but are not limited to cellular immunology and molecular biology e.g. enrichment and purification of human CD4+ T cells from peripheral blood, multicolor flow cytome-try, cell sorting using a BD FACS Aria III cell sorting system, functional T cell assays, DNA purification, real-time PCR, high resolution melting PCR, pyrosequencing and the targeted manipulation of methylation using fusion proteins. We are a looking for highly motivated and enthusiastic new additions to our young research team – most important for us is your interest in science. For further details please contact: Martin Scherm - martin.scherm@helmholtz-muenchen.de - 089 3187 1032 Institute of Diabetes Research 1 Independent Young Investigator Group Immune Tolerance in Type 1 Diabetes

Wenn Sie selbst eine Diplomarbeit ausschreiben wollen, lesen Sie bitte vorher unbedingt das 'Best Practice Manual Stellenanzeigen'.


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Kontakt: verena.ott@helmholtz-muenchen.de

28.01.2016
Praktikum/Masterarbeit am Institut für Diabetes Forschung am Helmholtz Zentrum München

Internship (8-10 weeks) with the possibility of consequent Master’s thesis available The epidemic of the metabolic syndrome, with obesity and type-2 diabetes at its core, represents one of the most severe health threats to the modern society. There is an increasing realization that obesity affects the immune system, promoting inflammation, and potentially leading to a variety of chronic conditions and diseases. Regulatory T cells and T follicular helper cells are essential in maintaining immune regulation and local homeostasis. Further, microRNAs (miRNAs), a class of evolutionary conserved small non- coding RNAs, control gene expression by targeting mRNAs for degradation or translational repression. Thereby, miRNAs participate in the regulation of the mammalian immune system by e.g. controlling T cell activation and function during inflammatory processes in the state of obesity. MiRNA expression profiles identified by next generation sequencing (NGS) analyses might function as attractive markers indicating different states of ongoing immune activation. The current project is offered in order to study frequencies and induction of T follicular helper cells in murine samples as well as in various blood samples from obese and individuals with T2D in comparison to healthy controls and to characterize miRNA expression profiles in these samples and correlate them to mRNA expression profiles. Methods to be employed include, but are not limited to cellular immunology and molecular biology e.g. enrichment, purification, and characterization of murine and human T follicular helper cells from lymph nodes and peripheral blood, multicolor flow cytometry, cell sorting using a BD FACS Aria III cell sorting system, functional T cell assays, RNA purification, real-time PCR analyses. We are looking for highly motivated and enthusiastic new additions to our young research team. Previous knowledge in immunology is not obligatory, most important for us is your interest in science. For further details please contact: Verena Ott e-mail: verena.ott@helmholtz-muenchen.de phone: +49 89- 3187 2189 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Institute of Diabetes Research 1 (IDF1) Independent Young Investigator Group Immunological Tolerance in Type 1 Diabetes Group Leader: Dr. Carolin Daniel Ingolstädter Landstraße 1 85764 Neuherberg or send your applicate by sending your Curriculum Vitae (CV) including some information about your practical lab experience.
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Kontakt: verena.ott@helmholtz-muenchen.de

27.01.2016

Neuronale Netze zur Klassifizierung von Kristallen

Bachelorarbeit: KÜNSTLICHE NEURONALE NETZE ZUR KLASSIFIZIERUNG VON KRISTALLEN

Kristallisation, Neuronale Netze, Einzelkristalle, Aggregate, Formfaktoren
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Kontakt: tijana.kovacevic@mytum.de

25.01.2016
Bundesweite Analyse der Trainerausbildungsstruktur in der Deutschen Triathlon Union mit dem Ziel einer einheitlichen Ausbildungsstrategie (Bachelor-/Zulassungsarbeit)

Die Trainerausbildung ist neben der Talentrekrutierung eine der wichtigsten Maßnahmen im Leistungs- und Hochleistungssport; denn nur durch eine qualitativ hochwertige und vor allem einheitliche Ausbildung von Trainern kann ein zielgerichtetes Training zum Erfolg führen. Aus diesem Grund sollen im Rahmen dieser Arbeit folgende Hauptfragen untersucht werden: 1) Welche Lehrkonzepte existieren in den einzelnen Landesverbänden im Triathlonsport? 2) Welche Anforderungen werden heutzutage an einen Triathlon-Trainer gestellt, die in einem Ausbildungskonzept berücksichtigt werden müssen? 3) Welche Fort- und Weiterbildungsmaßnahmen werden im Triathlonsport gefordert? Mit Hilfe einer bundesweiten Trainerbefragung soll ein einheitliches Lehr- und Lernkonzept erstellt werden, welches sich am Wandel des Triathlonsports orientiert, da diese Sportart längst keine Randsportart mehr ist. Beginn: ab sofort, Abschluss: Ende September 2016
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Kontakt: Dr. Martin Schönfelder, martin.schoenfelder@tum.de

22.01.2016
BACHELORTHESIS: (M/W) – SIMULATION OF MULTI-RATE SCHEDULES IN AUTOFOCUS3 (FB1-NOP-BAM-01-2016)

In this thesis you will develop a simulation of multi-rate schedules for distributed embedded systems. This simulation will be developed as part of the CASE tool AutoFOCUS3 (http://af3.fortiss.org) which is a powerful open-source tool to develop embedded systems using models from requirements to hardware architecture, passing by the design of the logical architecture, the deployment and the scheduling.
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Kontakt: career@fortiss.org

22.01.2016
Master Thesis

The goal of this master thesis is to utilize an atmospheric transport model to understand and quantify emissions of CO2 and CH4 from Munich and Berlin. WRF-CHEM simulation in combination with novel greenhouse gas concentration measurements will provide an insight of the emissions in these cities.
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Kontakt: jiachen@tum.de

20.01.2016
Master's thesis: Selection of a biphasic solvent system for the separation of natural product compounds using liquid-liquid chromatography (LLC)

This thesis will focus on the selection of a suitable biphasic solvent system for the liquid-liquid chromatography (LLC) separation of a natural product sample. After an initial literature search for solvent systems used in similar separations, COSMO-RS modeling software will be used to narrow down the possibilities by predicting solubilities and partition coefficients of the sample constituents. From a selected number of solvent systems, physicochemical properties measurements will be performed to determine, e.g., density, viscosity, settling time, and interfacial tension. The maximum sample solubility, as well as changes in the system properties as a result of sample concentration and temperature will also be explored. Lastly, selected systems will be evaluated on the basis of their stability within the LLC column.
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Kontakt: raena.morley@tum.de

20.01.2016
Master's thesis: Design and optimization of a centrifugal partition chromatography (CPC) process for the separation of natural product compounds

This thesis will focus on the design of a continuous centrifugal partition chromatography (CPC) separation process. Process parameters will first be optimized in the batch process, and then adapted to continuous operation. Along the way, design decisions will be made with the help of simulations performed using gPROMS ModelBuilder modeling software.
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Kontakt: raena.morley@tum.de

14.01.2016
Masterarbeit: Enzymatic activities in aquifer samples – Influence of interfering components

The potential of oxidative enzymes like peroxidases and laccases to degrade TOrCs have already been investigated and studies in managed aquifer systems (MAR) imply the involvement of even more enzymes like monooxygenase in TOrC degradation. Investigations in this area face difficulties due to complex mixtures of enzymes and complex matrices. In order to take advantage of enzymes as TOrC metabolizing biocatalyst, there is the need to establish a method to measure the enzymatic activity of enzymes in those samples. The methodological processes has already been applied and optimized to measure the enzymatic reactions in aquifer sample. However, it seems that ongoing processes are complex and that metal ions like Fe(II), pseudo peroxidases or humic substances play a role in substrate oxidation. Within the study project/ thesis experiments will be designed in order to investigate the impact of interfering factors. Therefore, different setups will be tested systematically so that finally the enzymatic activity in environmental samples can be assessed
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Kontakt: t.burkhardt@tum.de

12.01.2016
Masterarbeit: Untersuchung zur Herstellung thermoplastischer Bauteilstrukturen durch das Automated Fiber Placement Verfahren

Die Fertigung von Bauteilen aus faserverstärktem Kunststoff erfolgt zunehmend mit automatisierten Verfahren, wie z.B. dem thermoplastischen Automated Fiber Placement (TP-AFP). Dabei wird über einen robotergeführten Legekopf eine Bahn unidirektionaler Carbonfaserprepregs in der Bauteilform abgelegt. Dieser Prozess wird am LCC in Kooperation mit mehreren Industriepartnern untersucht und weiterentwickelt. Zur Erweiterung des Fertigungsspektrums des Prozesses soll die Machbarkeit der Fertigung reiner Kunststoffstrukturen untersucht werden. Es wurden bereits erfolgreiche Vorversuche durchgeführt auf die aufgebaut werden kann. Im Rahmen dieser Arbeit sollen weitere Ablageversuche durchgeführt werden. Die Ergebnisse sollen mit geeigneten Prüfmethoden charakterisiert werden um im Anschluss einen ersten Demonstrator fertigen zu können.
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Kontakt: engelhardt@lcc.mw.tum.de

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