Bachelor’s thesis/Internship (Lehrstuhl für Bioseparation Engineering)

05.08.2025, Studentische Hilfskräfte, Praktikantenstellen, Studienarbeiten

Evaluating Antibody Orientation on Chromatographic Resins Using Protein L

This project aims to evaluate the orientation of antibodies directly immobilized on chromatographic resins via covalent binding. Proper antibody orientation is critical to ensure that the antigen-binding sites are accessible and functional, which affects the performance of affinity-based separations.

Research Objective:
Test different chromatographic resins for antibody immobilization
To understand antibody orientation.
Identify which resin gives the best antibody orientation for capturing targets
Analytical Technique: SDS-PAGE, BCA assay.


Profile:
Structured and independent work
Motivation to work as a team/ willing to learn
Master/Bachelor student in chemical engineering, biotechnology (IBT, MBT),Pharmaceutical biotechnology biochemistry, chemistry, microbiology, biology or similar
Start date: as soon as possible.
Language: English
Ideal, but not required: Lab experience

Kontakt: t.khan@tum.de, y.kaveh@tum.de