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Sitemap > Bulletin Board > Studentische Hilfskräfte, Praktikantenstellen, Studienarbeiten > MASTERARBEIT Biologie- Platelet Heterogeneity in Patients with Coronary Syndromes
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MASTERARBEIT Biologie- Platelet Heterogeneity in Patients with Coronary Syndromes

31.07.2020, Studentische Hilfskräfte, Praktikantenstellen, Studienarbeiten

The Working group “Thrombosis and Antiplatelet Therapy” at the Department of Internal Medicine I at the Klinikum rechts der Isar München, Munich is devoted to research concerning the mechanisms and treatment of coronary artery related diseases as well as the detrimental role of reticulated platelets (RPs) in different pathological settings. Our laboratory inside the hospital Klinikum rechts der Isar is perfectly suited for combining basic research with clinically relevant issues.

RPs are promising novel biomarkers for the prediction of adverse cardiovascular events not only in cardiac patients but also during sepsis and after non-cardiac surgery. However, the reason for the intrinsic hyper-reactivity of RPs and for their association with ischemic adverse events has only recently been under investigation. The aim of this thesis is to validate the hyper-reactive behavior of RPs on the protein level via mass cytometry by time-of flight (CyTOF). Therefore, we will recruit different patients with chronic coronary syndrome (CCS) or myocardial infarctions. We will analyze platelet-rich plasma from healthy individuals and patients and compare different activation patterns. Data interpretation will be performed via the Cytobank software and in R. Thus, basic bioinformatic skills (e.g. python or R) and the willingness to learn and improve bioinformatic data analysis is required.

Supervision: Dr. med Dario Bongiovanni and PD Dr. med Isabell Bernlochner

Applications comprising a curriculum vitae and relevant documentations should be sent within a single PDF file via email to

Dr. med Dario Bongiovanni, email: bongiovanni@tum.de

Kontakt: bongiovanni@tum.de

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