Developing novel analytical tools to map the tumour microenvironment and study drug metabolism
2 PhD students (m/f/d) in Analytical Chemistry/Biomedical Mass Spectrometry
30.08.2024, Wissenschaftliches Personal
The Professorship for Analytical Chemistry of the TUM School of Natural Sciences is looking for two fully funded PhD students (m/f/d) starting Q1/Q2 2025: 1x Development of novel ion sources (instrumentation based), 1x Generating a database to map the TME. Our goal is to use the novel ion source for in the context of drug biotransformation in the TME.
Your tasks:
Tasks Position 1: Ion source development (instrumentation, based in Garching)
- You will put together an ion source based on Laser-Desorption Ionisation Rapid Evaporative Ionisation Mass Spectrometry (LDI-REIMS) for three purposes: i) High throughout analysis of cell cultures and microbes, (ii) High spatial resolution imaging applications, iii) In vivo longitudinal imaging of organotypic models
- You will put together an ion source based on Laser-Desorption Ionisation Rapid Evaporative Ionisation Mass Spectrometry (LDI-REIMS) for three purposes
- Together with PhD student 2 you will test these and perform optimisation studies
- Analysis of cell cultures to record a database of cells in the TME, frequent travel between the Garching and the Cytometry Core Facility at the MRI campus (Klinikum rechts der Isar) will be required
- Development of organotypic models to study drug metabolism in situ
- Cellular profiling and imaging using DESI and LDI-REIMS mass spectrometry as well as other imaging technologies (histological staining, spatial transcriptomics, imaging mass cytometry)
- Testing of the ion sources developed and optimisation together with PhD student 1
Profile Position 1
- Specialisation (MSc./Dipl.) in engineering or physics desired
- Students with other backgrounds (such as previous experience in instrumental mass spectrometry) who feel capable are encouraged to apply
- Practical experience with moving setups AND/OR lasers incl. building of laser optics
- Practical experience with programming desired
- Basic understanding of chemistry and physics, desire to learn about biomedical applications of MS and metabolomics
- Start date in Dec 2024 or Q1 2025
- Specialisation (MSc./Dipl.) in chemistry, biochemistry, analytical chemistry, immunology or related fields
- Experience with mass spectrometry AND/OR flow cytometry
- Interest in lipids and metabolism, cancer biology and pharmacology
- Willingness to travel between campuses
- Experience with programming (R, Matlab, Python) of advantage
- Start date in Q2 2025
We offer:
- Integration into a dynamic, international and multidisciplinary working environment with various national and international co-operations focussing on ambient mass spectrometry and its applications in the life sciences
- A constructive, lively working atmosphere
- Employment with appropriate remuneration for doctoral candidates, according to the collective agreement for the public service of the federal states (65% TV-L E13) for a duration of 3.5 years
- Structured doctoral programme (TUM Graduate School) and transferable skills training
- Opportunities to present your results at national and international meetings
If skills are comparable to other applicants, disabled candidates will be treated preferentially.
Contact:
Professur für Analytische Chemie
Prof. Dr. Nicole Strittmatter
Technische Universität München
School of Natural Sciences
Lichtenbergstr. 4
85748 Garching
https://www.bio.nat.tum.de/ach/home/
The position is suitable for disabled persons. Disabled applicants will be given preference in case of generally equivalent suitability, aptitude and professional performance.
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Kontakt: nicole.strittmatter@tum.de
More Information
https://www.bio.nat.tum.de/ach/home/