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Technische Universität München

Technische Universität München

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Scientist (PostDoc; m/w) for the development of antiinfective drug molecules

10.11.2017, Wissenschaftliches Personal

Our profile The group of Dr. Meyer at the Institut für Medizinische Mikrobiologie, Immunologie und Hygiene at the Technische Universität München is dedicated to developing innovative treatment options to meet the increasing threat by antibiotic resistances. In particular gram-negative, carbapenem-resistant infections pose a massive clinical challenge as there are very few - if any - treatment options left. We have identified two innovative molecule classes, which open novel therapeutic prospects. Within a BMBF funded project, we aim to further develop both compound classes in collaboration with two Helm-holtz Institutes in Neuherberg (structure analysis) and Braunschweig (medicinal chemistry). The focus of this project is the pathogen-targeted optimization of the compounds with respect to pathogen species, expressed antibiotic resistances, and other resistance enhancing mechanisms.

Your profile
 University degree in Biology, Biochemistry, Molecular Biotechnology, Pharmacy or comparable subjects with PhD degree
 Experience in handling pathogenic bacteria
 Expertise in antibiotic resistance mechanisms
 Experience in mass spectrometry and HPLC is a plus
 Experience in non- and pre-clinical drug development (preferably in a pharma setting)
 Accurate, diligent and reliable conduction of lab work
 Enthusiasm for translational science
 Excellent team spirit and communication skills
Your tasks
 Establish a collection of gram-negative clinical isolates
 Characterization of the bacteria with respect to antibiotic resistances and resistance-enhancing features
 Whole genome sequencing of the bacterial genomes
 Activity testing of inhibitory compounds in bacterial growth assays
 Establishing mass spectrometry based resistance assays
 Support in a first ADME/Tox profiling of inhibitors
We offer
 A highly motivated team dedicated to fight resistant infections
 Close collaboration with our in house diagnostic and medical microbiology department
 Fully equipped lab space in accordance with all safety regulations and in house expertise for work with patho-genic bacteria
 Insight into all aspects of early drug development (medicinal chemistry, ADME/Tox, in vivo infection models, intellectual property, regulatory, market analysis, financing strategies etc.)
 Full time position as scientist / PostDoc (m/w), currently terminated end of 2018
 Salary according to Tarifvertrag für den öffentlichen Dienst der Länder (TV-L)
 TUM seeks to increase the portion of female employees. Qualified females are, therefore, explicitly encoura-ged to apply
 Severely disabled persons with essentially comparable qualifications will be preferentially hired
Are you excited to secure treatment for infectious disease in the long run? If you like to join our team, please send your written application until November 30th 2017 to

If you have further questions, we are looking forward to your email or phone call!

Kontakt: Dr. Hannelore Meyer, TU-München, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Trogerstraße 30, 81675 München, Tel: +89 4140 6265, E-mail: Hannelore.Meyer@tum.de