The RPPA technology is a powerful multiplexed immunoassay that can quantitatively measure hundreds of proteins and post-translationally modified proteins (e.g. phosphorylated or cleaved) from a limited number of cells or a fraction of a biopsy. This simple, rapid diagnostic platform and the data derived from it is now being used by a growing number of basic research scientists, biomedical and pharmaceutical companies and CLIA laboratories to evaluate clinical tissue samples, cells, serum, and other biological fluids for basic discovery, translational research and even therapy-guiding assays. The methodology and applications for the technology is constantly evolving. Therefore, pioneers of the technology, experienced users and researchers interested in incorporating the RPPA technology into their portfolio will gather at the RPPA Global Workshop to discuss the technology’s applications for making advancements in personalized medicine; identifying therapeutic targets; discovering and validating biomarkers; and answering other biological questions. We will continue to build on the knowledge exchanged at the previous meetings in Houston (USA) 2011, Edinburgh (UK) 2012, Kobe (Japan) 2013, Paris (France) 2014, and Virginia (USA) 2015. Free exchange of knowledge will be shared in workshops, presentations, and technology showcases. The Global RPPA workshop is not only valuable for researchers who use the RPPA technology but also for researchers who would like learn about the principles and applications for RPPAs and gain hands-on training. Stay tuned for additional details.