In our group we are really interested to understand the interplay between genomics and epigenomics and their correlative and causal roles in health and disease. In the first part of my presentation I will present the epigenetic basis of learning and memory in healthy individuals and how this gene-regulatory network changes for different stimuli. The focus of the second part will be the reannotation of the human and murine exome using novel algorithms, the role of the exome in differential splicing, and the impact on patient diagnosis. I will finish with a brief description of our efforts to build new NGS analysis tools and biomarker discovery.