I will review the bioinformatics methods developed at the IIMCB and UAM and available via the genesilico.pl server. In particular, I will focus on meta-servers for prediction of protein structure, disorder, and evaluation of protein structure models. I will also briefly review our recent developments in the area of RNA 2D and 3D structure prediction and software for analyzing contact maps in proteins, nucleic acids and their complexes. I will introduce the GeneSilico TOOLKIT (available at https://genesilico.pl/toolkit/), a suite of tools for protein structural bioinformatics, available as an integrated web server. TOOLKIT provides a ‘one stop shop’ for researchers interested in predicting protein tertiary structure from sequence and in accurate estimation to which extent the structural models can be trusted.