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Mini cargo transporters on a rat run26.04.2012 - Kinesins assume a vital function in our cells: The tiny cargo transporters move important substances along lengthy protein fibers and ensure an effective transportation infrastructure. Biophysicists of the Technische Universitaet Muenchen (TUM) and the Ludwig Maximillians Universitaet Muenchen (LMU) have now discovered how some of these transporters can, like cars on a multi-lane motorway, change lanes. The researchers report on this hitherto unknown phenomenon in the current edition of the renowned journal “Molecular Cell.”
Mehr How probiotic bacteria protect against inflammatory bowel diseases25.04.2012 - Some lactic acid bacteria can alleviate inflammation and therefore prevent intestinal disorders. Scientists have now decoded the biochemical mechanism that lies behind the protective effect of the bacteria. In experiments with mice, the researchers succeeded in demonstrating that lactocepin – an enzyme produced by certain lactic acid bacteria – selectively degrades inflammatory mediators in diseased tissue. This new evidence might lead to new approaches for the treatment of inflammatory bowel diseases.
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Single-neuron observations mark steps in Alzheimer's disease20.04.2012 - Studying a mouse model of Alzheimer's disease, neuroscientists at the Technische Universitaet Muenchen have observed correlations between increases in both soluble and plaque-forming beta-amyloid – a protein implicated in the disease process – and dysfunctional developments on several levels: individual cortical neurons, neuronal circuits, sensory cognition, and behavior. Their results, published in Nature Communications, show that these changes progress in parallel and that, together, they reveal distinct stages in Alzheimer's disease with a specific order in time.
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